{"id":91548,"date":"2022-07-20T15:41:25","date_gmt":"2022-07-20T14:41:25","guid":{"rendered":"https:\/\/www.kidneyresearchuk.org\/?p=91548"},"modified":"2023-02-17T15:28:34","modified_gmt":"2023-02-17T15:28:34","slug":"making-vaccinations-work-better-for-patients-on-dialysis","status":"publish","type":"post","link":"https:\/\/www.kidneyresearchuk.org\/2022\/07\/20\/making-vaccinations-work-better-for-patients-on-dialysis\/","title":{"rendered":"Making vaccinations work better for patients on dialysis"},"content":{"rendered":"\r\n<p>Professor Alan Salama and his colleagues at University College London are building on their previous finding that the immune systems of dialysis patients don&#8217;t work as well as they should. We are thrilled to be able to support his work on making vaccinations work better for patients on dialysis.\u00a0<\/p>\r\n<h2>Explaining the problem<\/h2>\r\n<p>Patients whose kidneys fail are put on dialysis while they wait for a suitable donor kidney to become available. Dialysis machines take over the job of the kidneys and clean the patient&#8217;s blood. Dialysis has saved countless lives, however, there are some drawbacks. Dialysis weakens the immune system leaving an already vulnerable group more susceptible to illnesses. This has been particularly highlighted during the coronavirus pandemic.<\/p>\r\n<p>During the first waves of the pandemic, dialysis patients had a higher risk of hospitalisation and death from Covid-19 infection. Additionally, despite vaccination, some dialysis patients show little or no response in terms of building up immunity.<\/p>\r\n<p>On the other hand, patients with an autoimmune disease (conditions where an overactive immune system attacks the body), see an improvement if they are placed on dialysis. The reason behind these situations is not fully understood.\u00a0<\/p>\r\n<h2>Vaccine learning<\/h2>\r\n<p>Professor Alan Salama wants to help. They have previously found differences between dialysis patients, with some of them making more and some of them making fewer antibodies following vaccination. Alan wants to know why. By understanding the reasons behind this Alan and his team will be able to figure out how to manipulate the immune system to create more antibodies. This would mean that dialysis patients could be as effectively vaccinated as the general population. Not just against Covid-19 but other illnesses such as hepatitis and flu.\u00a0<\/p>\r\n<h2>What this means for kidney patients<\/h2>\r\n<p>We all suffered during the lock downs, but dialysis patients suffered more than most. If they were unable to dialyse at home, then they still had to dialyse in hospital, knowing full well that as a group they had worse outcomes in terms of hospitalisation and even death. We collectively took a sigh of relief when the vaccines were rolled out, knowing that this would be a path back to normality. Again, this was not necessarily the case for dialysis patients.<\/p>\r\n<p><img decoding=\"async\" class=\"lazyload\" title=\"Alan Salama headshot\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/2022\/07\/Alan-Salama-headshot-414x500.jpg\" alt=\"Professor Alan Salama\" width=\"414\" height=\"500\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Alan Salama headshot\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/2022\/07\/Alan-Salama-headshot-414x500.jpg\" alt=\"Professor Alan Salama\" width=\"414\" height=\"500\" \/><\/noscript> Professor Alan Salama<\/p>\r\n<p>When most people started to venture back out, many dialysis patients were still shielding. Alan&#8217;s work will enable dialysis patients to benefit from vaccinations just like everyone else. This is not just important for the coronavirus pandemic but will be essential for seasonal flu. Effective vaccinations will allow dialysis patients to participate fully in their communities without fear.\u00a0<\/p>\r\n<p>Alan said, &#8220;This grant will enable us to try an understand a critically important observation that we have known about but haven&#8217;t truly understood, which is why dialysis patients don&#8217;t respond to vaccines as well as patients with normal kidney function and why certain autoimmune diseases become quieter in patients on dialysis.<\/p>\r\n<p>&#8220;We will make use of the responses to the COVID vaccine to help identify good and bad responders, as well as patients with autoimmune diseases that have or have not relapsed on dialysis and explore differences in their immune systems.<\/p>\r\n<p>&#8220;Ultimately, we hope to find a way to boost the poor vaccine responses in those that need it and understand what we could do to better switch off autoimmune diseases in those with better kidney function&#8221;.\u00a0<\/p>\r\n<h2>More research news<\/h2>\r\n<p><a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/26\/funding-new-research\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"research\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/MR4_9152-crop-copy-500x389-landscape.jpg\" alt=\"research\" width=\"500\" height=\"389\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"research\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/MR4_9152-crop-copy-500x389-landscape.jpg\" alt=\"research\" width=\"500\" height=\"389\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Funding new research\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/26\/funding-new-research\/\"> Funding new research <\/a><\/h3>\r\n<p>26 July 2022 <a title=\"Funding new research\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/26\/funding-new-research\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/25\/understanding-transplant-rejection\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"salt\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/iStock_000007169515Small-500x333-landscape.jpg\" alt=\"Salt\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"salt\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/iStock_000007169515Small-500x333-landscape.jpg\" alt=\"Salt\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Understanding transplant rejection\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/25\/understanding-transplant-rejection\/\"> Understanding transplant rejection <\/a><\/h3>\r\n<p>25 July 2022 <a title=\"Understanding transplant rejection\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/25\/understanding-transplant-rejection\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/21\/predicting-acute-kidney-injury-risk-post-surgery\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"shutterstock_1017224248_blood_vessel\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/shutterstock_1017224248_blood_vessel-500x313-landscape.jpg\" alt=\"Blood vessels\" width=\"500\" height=\"313\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"shutterstock_1017224248_blood_vessel\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/shutterstock_1017224248_blood_vessel-500x313-landscape.jpg\" alt=\"Blood vessels\" width=\"500\" height=\"313\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Predicting acute kidney injury risk post-surgery\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/21\/predicting-acute-kidney-injury-risk-post-surgery\/\"> Predicting acute kidney injury risk post-surgery <\/a><\/h3>\r\n<p>21 July 2022 <a title=\"Predicting acute kidney injury risk post-surgery\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/21\/predicting-acute-kidney-injury-risk-post-surgery\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/20\/making-vaccinations-work-better-for-patients-on-dialysis\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"Dialysis chair\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/MicrosoftTeams-image-2-500x333-landscape.jpg\" alt=\"Dialysis chairs in a renal unit\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Dialysis chair\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/MicrosoftTeams-image-2-500x333-landscape.jpg\" alt=\"Dialysis chairs in a renal unit\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Making vaccinations work better for patients on dialysis\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/20\/making-vaccinations-work-better-for-patients-on-dialysis\/\"> Making vaccinations work better for patients on dialysis <\/a><\/h3>\r\n<p>20 July 2022 <a title=\"Making vaccinations work better for patients on dialysis\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/20\/making-vaccinations-work-better-for-patients-on-dialysis\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/11\/investigating-a-novel-treatment-for-nephrotic-syndrome-and-diabetic-nephropathy\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"Dr Carl May\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Dr-Carl-May-500x333-landscape.jpg\" alt=\"Dr Carl May\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Dr Carl May\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Dr-Carl-May-500x333-landscape.jpg\" alt=\"Dr Carl May\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Investigating a novel treatment for nephrotic syndrome and diabetic nephropathy\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/11\/investigating-a-novel-treatment-for-nephrotic-syndrome-and-diabetic-nephropathy\/\"> Investigating a novel treatment for nephrotic syndrome and diabetic nephropathy <\/a><\/h3>\r\n<p>11 July 2022 <a title=\"Investigating a novel treatment for nephrotic syndrome and diabetic nephropathy\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/11\/investigating-a-novel-treatment-for-nephrotic-syndrome-and-diabetic-nephropathy\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/06\/developing-dietary-phosphate-education-resources-for-children-and-young-people\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"Vegetables\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/iStock_000010145978Small-2-500x331-landscape.jpg\" alt=\"Vegetables\" width=\"500\" height=\"331\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Vegetables\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/iStock_000010145978Small-2-500x331-landscape.jpg\" alt=\"Vegetables\" width=\"500\" height=\"331\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Developing dietary phosphate education resources for children and young people\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/06\/developing-dietary-phosphate-education-resources-for-children-and-young-people\/\"> Developing dietary phosphate education resources for children and young people <\/a><\/h3>\r\n<p>6 July 2022 <a title=\"Developing dietary phosphate education resources for children and young people\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/06\/developing-dietary-phosphate-education-resources-for-children-and-young-people\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/05\/new-results-from-pivotal-trial\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"pivotal-trial-patient-nurse\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/pivotal_Elizabeth_Clarke_Mimi_Hoare-500x281-landscape.jpg\" alt=\"Pivotal trial patient, Mimi Hoare, and nurse, Elizabeth Clarke\" width=\"500\" height=\"281\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"pivotal-trial-patient-nurse\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/pivotal_Elizabeth_Clarke_Mimi_Hoare-500x281-landscape.jpg\" alt=\"Pivotal trial patient, Mimi Hoare, and nurse, Elizabeth Clarke\" width=\"500\" height=\"281\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"New results from PIVOTAL trial\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/05\/new-results-from-pivotal-trial\/\"> New results from PIVOTAL trial <\/a><\/h3>\r\n<p>5 July 2022 <a title=\"New results from PIVOTAL trial\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/05\/new-results-from-pivotal-trial\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/04\/looking-for-ways-to-improve-treatments-for-nephrotic-syndrome\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"Prof Moin Saleem (6)\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Prof-Moin-Saleem-6-500x333-landscape.jpg\" alt=\"Prof Moin Saleem\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Prof Moin Saleem (6)\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Prof-Moin-Saleem-6-500x333-landscape.jpg\" alt=\"Prof Moin Saleem\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Looking for ways to improve treatments for nephrotic syndrome\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/04\/looking-for-ways-to-improve-treatments-for-nephrotic-syndrome\/\"> Looking for ways to improve treatments for nephrotic syndrome <\/a><\/h3>\r\n<p>4 July 2022 <a title=\"Looking for ways to improve treatments for nephrotic syndrome\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/04\/looking-for-ways-to-improve-treatments-for-nephrotic-syndrome\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/01\/improving-outcomes-for-patients-born-with-posterior-urethral-valves\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"Dr David Long (1)\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Dr-David-Long-1-500x333-landscape.jpg\" alt=\"Professor David Long in the research lab\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Dr David Long (1)\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Dr-David-Long-1-500x333-landscape.jpg\" alt=\"Professor David Long in the research lab\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Improving outcomes for patients born with posterior urethral valves\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/01\/improving-outcomes-for-patients-born-with-posterior-urethral-valves\/\"> Improving outcomes for patients born with posterior urethral valves <\/a><\/h3>\r\n<p>1 July 2022 <a title=\"Improving outcomes for patients born with posterior urethral valves\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/07\/01\/improving-outcomes-for-patients-born-with-posterior-urethral-valves\/\">Read More<\/a> <a href=\"https:\/\/www.kidneyresearchuk.org\/2022\/06\/30\/kidney-beam-for-kids\/\" target=\"_self\" rel=\"noopener\"> <img decoding=\"async\" class=\"lazyload\" title=\"Pamela Scarborough Beam Co-Founder\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Pamela-Scarborough-Beam-Co-Founder-1-500x333-landscape.jpg\" alt=\"Pamela Scarborough, Beam Co-Founder\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><noscript><img decoding=\"async\" class=\"lazyload\" title=\"Pamela Scarborough Beam Co-Founder\" src=\"https:\/\/www.kidneyresearchuk.org\/wp-content\/uploads\/bb-plugin\/cache\/Pamela-Scarborough-Beam-Co-Founder-1-500x333-landscape.jpg\" alt=\"Pamela Scarborough, Beam Co-Founder\" width=\"500\" height=\"333\" data-no-lazy=\"1\" \/><\/noscript> <\/a><\/p>\r\n<h3><a title=\"Kidney-BEAM for kids\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/06\/30\/kidney-beam-for-kids\/\"> Kidney-BEAM for kids <\/a><\/h3>\r\n<p>30 June 2022 <a title=\"Kidney-BEAM for kids\" href=\"https:\/\/www.kidneyresearchuk.org\/2022\/06\/30\/kidney-beam-for-kids\/\">Read More<\/a><\/p>\r\n<!-- .pp-content-posts -->\r\n<h2>Why not make a donation now?<\/h2>\r\n<p>(Every \u00a3 counts)<\/p>\r\n<p><a role=\"button\" href=\"https:\/\/kidneyresearchuk.org\/support\/donate\/\" target=\"_self\" rel=\"noopener\"> Donate now <\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>Professor Alan Salama and his colleagues at University College London are building on their previous finding that the immune systems of dialysis patients don&#8217;t work as well as they should. We are thrilled to be able to support his work on making vaccinations work better for patients on dialysis.\u00a0 Explaining the problem Patients whose kidneys&hellip;<\/p>\n","protected":false},"author":3,"featured_media":69663,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_searchwp_excluded":"","footnotes":""},"categories":[311,264,319,29],"tags":[],"class_list":["post-91548","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study","category-coronavirus","category-dialysis","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Making vaccinations work better for patients on dialysis - Kidney Research UK<\/title>\n<meta name=\"description\" content=\"Researching how to create more antibodies so that dialysis patients can be effectively vaccinated 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